WebFeb 19, 2024 · IRE1 is a type I ER transmembrane protein that consists of an ER-luminal domain, which acts as an unfolded protein sensor during ER stress, and cytosolic … WebApr 11, 2024 · Pipeline for particle picking in cryo-electron microscopy images using convolutional neural networks trained from positive and unlabeled examples. Also featuring micrograph and tomogram denoising with DNNs. machine-learning cnn pytorch object-detection cryo-em topaz denoising cryoem particle-picking positive-unlabeled topaz …
Parallel cryo electron tomography on in situ lamellae
WebInositol-requiring enzyme 1 (IRE1) is an ER transmembrane sensor that activates the UPR to maintain the ER and cellular function. Although mammalian IRE1 promotes cell survival, it … WebDec 1, 2024 · In recent years, cryo electron tomography (cryoET) has been rapidly gaining popularity in the field of structural biology. Its capability to resolve molecular structures in their native cellular... saga horse racing
IPET and FETR: Experimental Approach for Studying …
WebThe Cryo-Electron Microscopy (cryo-EM) Core at the Penn State College of Medicine was established in 2024 through the financial support of the Office for the Vice Dean of Research and the Pennsylvania Department of Health Tobacco Settlement Funds (CURE). WebProfessor Hong Zhou’s lab focuses on 3D structural studies of biological complexes using cryo-electron microscopy (cryoEM) and cryo-electron tomography (cryoET). These emerging methods are particularly suitable for structure determination of large molecular complexes, viruses, cellular machineries and bacterial cells. WebFeb 4, 2024 · IRE1 is a transmembrane protein composed of three distinct domains, a sensing domain in the ER lumen, connected through a transmembrane segment to a cytosolic regulatory kinase domain, and finally a C-terminal RNase domain. Upon ER stress, IRE1 is activated to ultimately result in the noncanonical splicing of the mRNA encoding … they work for you johnny mercer