Phenprocoumon metabolismus
WebCytochrome P450 (CYP) 2C9 has clearly been established as the predominant catalyst responsible for the metabolism of its more potent S-enantiomer. More recently, CYP2C9 has also been reported to catalyse the hydroxylation of phenprocoumon and acenocoumarol. WebPhenprocoumon C18H16O3 CID 54680692 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
Phenprocoumon metabolismus
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WebIn nine patients, the synthesis rate Rsyn of the vitamin K-dependent clotting factors was calculated from changes in prothrombin-complex activity after intravenous administration of a synthesis-blocking dose of phenprocoumon (PPC). The biological half-life of PPC was between 2.70 and 7.01 days. No correlation was found between the level of the free … WebAs phenprocoumon is metabolized by hydroxylation as well as by direct glucuronidation, the increased clearance may mean that induction of the latter process over-rides inhibition of …
WebPhenprocoumon C18H16O3 CID 54680692 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … WebPhenprocoumon is the dominant anticoagulant in clinical use in several continental European countries. It used for the prevention and treatment of thromboembolic disease including venous thrombosis, thromboembolism, and pulmonary embolism as well as for the prevention of ischemic stroke in patients with atrial fibrillation.
WebThis is the first occasion when phenprocoumon metabolites have been identified in plasma; they were unconjugated and in much lower concentrations (43.2 and 2 ng/ml for the 7,4′ … WebOct 31, 2024 · Phenprocoumon is not approved for sale by the U.S. Food and Drug Administration (FDA). Limited information indicates that anticoagulant maternal doses of …
WebPhenprocoumon belongs to the group of vitamin K antagonists (VKAs), for example warfarin and acenocoumarol. It is widely used for therapeutic anticoagulation and clinically administered as a racemate. Both enantiomers are partially metabolized by the polymorphic CYP2C9 enzyme. The pharmacokinetics a …
WebApr 18, 2024 · Phenprocoumon ist in Deutschland das am häufigsten verwendete Cumarin-Derivat - im Rest der Welt wird dagegen überwiegend Warfarin eingesetzt. Es wird nach … fenelon falls ontario historyWebPhenprocoumon belongs to the group of vitamin K antagonists (VKAs), for example warfarin and acenocoumarol. It is widely used for therapeutic anticoagulation and clinically … fenelon falls weather 14 dayWebPhenprocoumon is a Vitamin K Antagonist. The mechanism of action of phenprocoumon is as a Vitamin K Inhibitor. 1 2D Structure 2 Identification 2.1 Computed Descriptors 2.1.1 IUPAC Name 4-hydroxy-3- (1-phenylpropyl)chromen-2-one 2.1.2 InChI InChI=1S/C18H16O3/c1-2-13 (12-8-4-3-5-9-12)16-17 (19)14-10-6-7-11-15 (14)21-18 … fenelon falls ontario real estateWebThe synthesis of deuterium labelled 4′-,6-,7- and 8-hydroxy metabolites of warfarin and phenprocoumon is described. The pentadeuterio labelled 6-,7- and 8-hydroxyphenprocoumons were prepared via alkylation of the respective 6-, 7- and 8-methoxy-4-hydroxycoumarins with 1-(phenyl-d 5)-1-bromopropane and subaequent cleavage of the … fenelon falls united churchWebAcenocoumarol (ACE), phenprocoumon (PPC) and warfarin (WFN) are commonly used for the causal or prophylactic oral treatment of venous and arterial thrombosis (vitamin … deichgraf london dry ginWebThe dose-dependency of phenprocoumon disposition was determined in rats by iv administration of 0.1 and 1.0 mg/kg doses to separate groups of animals. The intrinsic … fenelon falls rotary club car drawWebnoun. phen· pro· cou· mon ˌfen-prō-ˈkü-ˌmän. : an anticoagulant drug C18H16O3. fenelon falls thrift store