Plk1 and fibrosis
Webb1 nov. 2024 · PLK1 is absolutely indispensable for the initiation of centrosome maturation and for the formation of a bipolar spindle, as PLK1 inhibition leads to monopolar spindle formation with impaired microtubule organizing activity [65], [66], [67]. Download : Download high-res image (676KB) Download : Download full-size image Fig. 2. WebbIPF, idiopathic pulmonary fibrosis. from publication: Pan-transcriptome-based candidate therapeutic discovery for idiopathic pulmonary fibrosis Background: There are two US Food and Drug ...
Plk1 and fibrosis
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Webb7 maj 2024 · A PLK1 kinase assay was performed using the purified active form of PLK1 (T210D) and GST-tagged vimentin as a substrate for PLK1 in reaction buffer containing … Webb1 nov. 2024 · PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M …
WebbPLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β‐catenin signalling pathway Yu Chen School of Pharmacy, Anhui Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative … WebbContext: Polo-like kinase 1 (PLK1) is a critical molecule in the proliferation of several human cancers. Overexpression of PLK1 has been correlated with cancer cell …
Webb15 feb. 2024 · Interestingly, the transcription factor FOXM1 has been recently found to play a key role in lung fibrogenesis through the upregulation of profibrotic and prosurvival … Webb11 apr. 2024 · UBAP2L ensures proper chromosome segregation during mitosis. UBAP2L-mediated regulation of PLK1 is independent of stress signaling. UBAP2L controls both …
Webb15 juni 2024 · Myofibroblasts promote fibrosis in multiple organs, including the lungs. In this study, we identified PLK1 as a promoter of myofibroblast differentiation and …
Webb10 aug. 2008 · The kinase Plk1 regulates multiple processes during mitosis in mammalian cells. Chen and colleagues show that Plk1 also controls a transcriptional network … boca raton stroke treatmentWebbPLK signaling pathway . PLK signaling pathway cascade. PLK1 mainly assists the functional maturation of the centrosome and the formation of the spindle in the late G2 to the early stage of M, thereby promoting the entry of cells into the M phase; and it simultaneously participates in the activation of the cell cycle regulator CDC25, which in … clockhouse caWebb2 feb. 2024 · Hee-Young Jeon, Majid Pornour, Hyunju Ryu, Sudeep Khadka, Rui Xu, Jihyun Jang, Deqiang Li, Hegang Chen, Arif Hussain, Ladan Fazli, Martin Gleave, Xuesen Dong, Furong Huang, Qianben Wang, Christopher Barbieri, Jianfei Qi, SMAD3 promotes expression and activity of the androgen receptor in prostate cancer, Nucleic Acids … clockhouse burnhamboca raton steakhouseWebbSince Plk1 expression is limited to proliferating cells, interference with Plk1 function results in apoptotic cell death in various tumor cells but not in normal cells.6,10,12 Multiple lines of evidences have made Plk1 a promising target for the development of novel anticancer drugs. In fact, several small molecule inhibitors against Plk1 have clock house b\u0026b marnhullWebbMetabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma Metabolic … clockhouse cWebb12 juli 2024 · In fact, several challenges are restraining the clinical utility of PLK1 inhibitors. First, most of the PLK1 inhibitors achieved therapeutic effects only when doses exceeded toxic limits. Second, the responses to PLK1 inhibitors reported from different studies were discrepant. Finally, the emergence of drug resistance is a major challenge [ 1, 3 ]. clockhouse cabin