WebJun 4, 2024 · The protein levels in NF-kB signaling was estimated by western blotting and immunoprecipitation assays were applied to demonstrate the direct interaction between … WebJul 1, 2024 · As a transcription factor, p53 functions as a homotetramer and binds to the p53-responsive elements in p53 target genes to transcribe these genes in cells. 12, 13 The p53-responsive element is composed of two decamers separated by a spacer of 0–14 nucleotides: RRRCWWGYYY (spacer) RRRCWWGYYY, where R is a purine, W is A or T, and …
TRIM37, a novel E3 ligase for PEX5-mediated peroxisomal matrix protein …
WebFeb 27, 2024 · PI3K/AKT inhibitor LY294002 abolished the function of TRIM37 on cell proliferation in human MOLT-4 cells. To further study whether TRIM37 regulate the proliferation of human T-ALL cells through AKT signaling pathway, MOLT-4 cell line stably expressing TRIM37 was established by lentivirus transfection. WebNov 15, 2024 · In this study, we unveiled a novel function of TRIM37 in regulating nuclear-to-cytoplasmic NF-κB signaling. We found that, upon genotoxic stimulation, TRIM37 rapidly translocated into the nucleus where it interacted directly with TRAF6 to catalyze monoubiquitination of NEMO at K309. how to simplify an expression with variables
The Journal of Pathology
WebJun 27, 2024 · A number of centrosome-related TRIM37 functions have been described. In the absence of TRIM37, a collection of centriole proteins such as CNTROB, PLK4, CETN1/2, CP110 accumulate to form aberrant assemblies referred to as condensates or ‘Cenpas’ (centriolar protein assemblies) (Balestra et al., 2024; Meitinger et al., 2024). WebDevelopmental and speech delay due to SOX5 deficiency is a rare genetic syndromic intellectual disability characterized by mild to severe global developmental delay, intellectual disability and behavioral abnormalities, hypotonia, strabismus, optic nerve hypoplasia and mild facial dysmorphic features (down slanting palpebral fissures, frontal bossing, … WebNov 1, 2024 · Tripartite motif 37 (TRIM37), a member of the TRIM protein family, was involved in the tumorigenesis of several types of cancer. However, the expression pattern … how to simplify an image